Available online Jul 18, 2018.
[ Original ] Volume 23, Issue 2, 2014, Pages 130-141
BACKGROUND: Herpes Simplex Virus infection is a chronic infection of the sensory ganglia with variable levels of
epithelial expression. An important feature of HSV infection is the recurrence of disease as a result of periodic or
sporadic activation of viral replication. In addition, asymptomatic shedding of herpes viruses may play a significant
role in transmission from person to person.This infection being lifelong manifests only in a small proportion of those
infected. It has presented public health concern because of its progressively increasing prevalence which some
reports say is of epidemic proportion in developing countries and also for its synergistic effect with HIV infection.
OBJECTIVES: Determination of antibody prevalence to HSV-2 / co-infection with HIV among females attending skin
and ANC clinics in UNTH and ESUTH.
MATERIALS AND METHODS: One hundred and eighty suitably qualified subjects were appropriately recruited
over a period of six months into this study. Essential information was collected using a questionnaire. Venous blood
was also obtained for HSV 2 serology, HIV screening, and confirmation, if positive.
RESULTS: The antibody prevalence of HSV 2 was found to be 77.8% (n=137) and 14.6% (n=20) had clinical
diagnosis. The HIV and HSV-2 co-infection rate was 5.11% (n=9). The risk factors for groups 1[HSV2 Infection] and
2[HSV2 & HIV co-infection] were similar with few differences, thus buttressing the fact that their modes of
transmission are similar.
CONCLUSION: Factors influencing Herpes simplex virus type 2 infection among females in Enugu included among
other things older age and increasing number of lifetime sexual partners.
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Volume 23 | Issue 2
Page Nos. 130-141
Online since Jul 13, 2018