EVALUATION OF MALE SEX HORMONES AND TRACE ELEMENTS IN MALE TYPE 2 DIABETIC PATIENTS ATTENDING NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL DIABETIC CLINICS

Ubajaka C.F, Meludu S.C, Dioka C.E, Onah C.E, Osuji C.U, Modebe I.A, 1 2 2 1 Ifeadike G.C, Okwara J.E, Amah U.K, Nnebue Cc

Available online Jul 19, 2018.

[ Original ] Volume 24, Issue 2, 2015, Pages 162-168


Abstract

BACKGROUND
There is accumulating evidence that the metabolism of male sex hormones and several trace elements are altered
in type 2diabetic mellitus and may have specific role in the pathogenesis and progression of the disease.
AIM
To assess the levels of male sex hormones and trace elements in type 2 diabetic patients and to ascertain an
association between male sex hormones and trace elements among diabetic subjects.
METHODS
A descriptive cross sectional study was conducted among 125 diabetic and 50 non diabetic subjects.Venous blood
samples were collected from all respondents and estimated for fasting blood glucose,male sex hormones and trace
elements. The results were subjected to statistical analysis and comparison using Students' test and Pearson
correlation analysis.
RESULTS
The mean testosterone level was significantly lower in diabetics than in controls (3.9± 1.9ng/ml) in comparison
with (5.1± 1.7ng/ml;P<0.05).The mean value of Zinc,Manganese,Selenium and Chromium were significantly lower
among the diabetics when compared with the controls (Zn;898.7± 131.0μg/l;Mn:0.30± 0.06μg/l;Se:51.3± 11.1μg/l;
Cr: 0.04± 0.03μg/l) in comparison with (Zn: 1007.3± 85.2μg/l; Mn: 0.05± 0.07μg/l; Se: 62.1± 11.1μg/l; Cr: 0.06±
0.01μg/l;P<0.05).The mean Fasting Blood Glucose in diabetic subjects was significantly higher when compared with
the controls (7.9± 3.7mmol/l) in comparison with (4.6± 0.4mmol/l; P<0.05).The trace elements showed a positive
correlation with testosterone in diabetic subjects (Zn r= 0.359,Se r= 0.443,Mn r= 0.350,P<0.05).
CONCLUSION
This study observed decreased levels of testosterone and trace elements in type 2 diabetics and a positive
correlation between low testosterone and low trace elements levels in diabetic subjects.These trace elements are
antioxidants and their low levels in diabetic patients may further increase the severity of the disease


Keywords

Testosterone, Zinc, Selenium, Manganese, Diabetes Mellitus,