MORTALITY PATTERN AMONG TUBERCULOSIS PATIENTS ON TREATMENT IN NIGERIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Musa B. M, Bashir H.A, Uloko A.E, Garbati M.A, Bakki B, Gumi H.S, Yusuf A, Bello Manga H

Available online Apr 29, 2020.

[ Review ] Volume 29, Issue 1, 2020, Pages 158-162


Abstract

Background: Tuberculosis (TB) has continued to be associated with a substantial number of deaths, even in the era of effective antimicrobials. Nigeria is one of the countries with a high tuberculosis burden and has sub-optimal documentation of TB related deaths. Vital statistics/registration is not robust, and mortality surveys are rarely undertaken. In this study, we aimed to determine a precise estimate of TB related deaths on treatment and the trends in death rate while on TB treatment in Nigeria.

Methods: We searched electronic databases for eligible studies from 1st January 2000 to 31st December 2017. We generated pooled death rate estimates using random-effects models and determined trends using meta-regression.

Results: We identified 546 studies, of which 28 fulfilled the criteria for quantitative analysis. Overall, studies reported on 64,999 individuals. The pooled TB death  rate during treatment was 6.6% (95% CI; 5.2-8.1%). There was a non-significant rise in TB related deaths on treatment of 0.2% per year (p-value = 0.454).

Conclusion: We found a low TB related deaths on treatment, death rate and slight temporal rise over the study years. There is a need for continuous vital registration, including TB related death, and mortality survey among TB patients.

 


Keywords

Tuberculosis, mortality, death,

JANUARY - MARCH 2020

Volume 29 | Issue 1

Page Nos. 158-162

Online since Jan 28, 2020

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