DETERMINANTS OF ANTIRETROVIRAL THERAPY ADHERENCE AMONG HIV-INFECTED ADOLESCENTS ATTENDING A TERTIARY HEALTH FACILITY IN ABUJA, NIGERIA

EkopEno E, OkechukwuAdaora A, Airede Kareem I.

Available online May 1, 2020.

[ Original ] Volume 29, Issue 1, 2020, Pages 80-87


Abstract

Background: An adherence level of = 95% is required for antiretroviral therapy success. Several factors affect adolescent adherence to ARV therapy but there is paucity of data in developing countries for this age group.

Aim/Objectives: The study aim was to determine the proportion of HIV-infected adolescents' adherent to antiretroviral therapy using self-report and pill count, and to identify barriers to adherence. Methods: A prospective cohort study carried out at University of Abuja Teaching Hospital, Nigeria. Adolescents were assessed and followed up every 2 months for 6 months.

Results: One hundred and thirty-five results were analysed. Adherence using self-report and pill count were 88.9% and 66.7%, respectively. A significant association was found between adherence using self-report and; adolescents' social class (P= 0.006, OR=1.69 CI 0.23 – 19.4); adolescents' religion (P= 0.0196 OR= 3.51 CI 1.12-14.48); and level of education of the primary caregiver (P= 0.039 OR= 0.145 CI 0.014-2.15). The relationship between adherence using pill count and the variables assessed was not significant. The foremost barrier to adherence was forgetting (n=57; 42.22%), the second and third being running out of medications from missed clinic appointments (n= 17; 12.59%) and refusal to take medications (n=5; 3.7%), respectively.

Conclusion: Adherence was higher when measured using self-report. Adherence measurement is recommended at every clinic appointment using more than one method. There is a need for better reminder systems to curb forgetfulness in taking ARV drugs among adolescents.


Keywords

Adherence, adolescent, antiretroviral, HIV, barriers.,

JANUARY - MARCH 2020

Volume 29 | Issue 1

Page Nos. 80-87

Online since Jan 28, 2020

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