MATERNAL GENITAL TRACT COLONIZATION AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF STREPTOCOCCUS AGALACTIAE: A MODALITY FOR INTRAPARTUM PROPHYLACTIC TREATMENT IN JOS

Dahal A. Samuel, Sabitu M. Zainu, Helen D. Nanbol, Mark O. Okolo, Nakah J. Nababa, Nanma Dashe, Daniel Z. Egah, Kandakai-Olukemi, Y.T.

Available online Dec 18, 2019.

[ Original ] Volume 28, Issue 3, 2019, Pages 266-274


Abstract

 

BACKGROUND: Group B Streptococcus agalactiae (GBS) has been established as a normal flora of the gastrointestinal tract from where it

 

 

 

continually colonizes the vagina and serves as a potential cause of neonatal infections. This necessitated this study to determine the carriage

 

rate among pregnant women.

AIM: The aim of this study was to determine the anogenital colonization and antibiotic susceptibility of Streptococcus agalactiae isolates from

 

 

 

women receiving health care at the Jos University Teaching Hospital (JUTH).

MATERIALS AND METHODOLOGY: This was a hospital based descriptive cross-sectional study of 200 pregnant women and 100 non-pregnant

 

 

 

women attending antenatal clinic (ANC) and Gynaecology clinic at the Jos University Teaching Hospital respectively, between July 2017 and

 

November 2017. High vaginal and anorectal swabs were collected from the subjects. The specimens were cultured and antibiotic susceptibility

 

testing of the GBS isolates determined. The results obtained were analyzed using SPSS version 21.

RESULTS: The age range (standard deviation) of the pregnant women was between19-48(±7.2) years with an average age of 31.2 years. The

 

 

 

overall prevalence rate of GBS among the study participants was 6.3%. Pregnant and non-pregnant women were positive in 6.5% and 6.0%

 

respectively.

 

The highest colonization rate was found in the maternal age-group 16-20years (11.1%), followed by age-group>40years (10.0%). Low

 

colonization rate of 2.2% was observed among maternal age group 36-40years.Of the 100 non-pregnant women recruited as control for this

 

study, they had age range of 16 years to 48 years with a mean age of 33.4 years (SD ± 6.1). Approximately, 6.0% of the 100 non-pregnant women

 

enrolled were cultured positive for GBS colonization. There was no statistically significance between GBS colonization between the pregnant

 

and non-pregnant women. All the Isolates were sensitivity to penicillin, erythromycin, and clindamycin while 5.3% were resistant to ampicillin,

 

10.5% to ceftriaxone and 21.1% to vancomycin.

CONCLUSION: This study showed that GBS colonization rate among the study population was 6.3%. Approximately, 6.5% and 6.0% prevalence

 

 

 

rate was found among pregnant and non-pregnant women respectively. All the isolates were sensitive to penicillin, erythromycin and

 

clindamycin. A total of 21.5% of the isolates were resistant to vancomycin. Ceftriaxone and ampicillin resistant was demonstrated in 10.5% and

 

5.3% respectively.

 


Keywords

Streptococcus agalactiae, colonization rate, pregnant women, antibiotic susceptibility.,

JULY - SEPTEMBER 2019

Volume 28 | Issue 3

Page Nos. 266-274

Online since Dec 17, 2019

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