Available online Jul 13, 2018.
[ Review ] Volume 19, Issue 4, 2010, Pages 361-368
Background: The human immunodeficiency
virus/acquired immunodeficiency syndrome pandemic
have posed a significant public health challenge to the
global community. Massive therapeutic interventions with
antiretroviral drugs are being undertaken, yet problems
and challenges exist. This review examines these
problems and challenges as they affect the treatment of
HIV infection in resource-poor countries such as Nigeria.
Methods: The information was sourced from relevant
literature using human immunodeficiency virus/acquired
immunodeficiency syndrome journals, textbooks and
Websites on human immunodeficiency virus/acquired
immunodeficiency syndrome, highly active antiretroviral
therapy, resource-poor countries as key words.
Results: Several studies have shown that the advent of
highly active antiretroviral therapy in 1996 has
significantly reduced morbidity and mortality among
people living with HIV/AIDS (PLWHA). But in resourcepoor
countries, initiation and maintenance of highly active
antiretroviral therapy has been associated with many
challenges and problems such as: poor infrastructural
base for the control programs; irregular or non availability
of drugs; poor drug adherence; co-morbidities and
opportunistic infections/malignancies; drug toxicities;
drug/food and drug/drug interactions; laboratory
monitoring of viral load; CD4 cell counts; full blood counts;
electrolytes, kidney and liver functions.
Conclusion: The review has shown that the solution to
the pandemic lies in a multi-sectoral and holistic approach
involving International and local agencies, and communities.
Subscribe to have full access to PDF format of all articles and get print copy of Nigerian Medical Journal.
Volume 19 | Issue 4
Page Nos. 361-368
Online since Jul 13, 2018