Serum C-Reactive Protein in Nigerians With Type 2 Diabetes Mellitus

Baba MM, Kolawole BA, Ikem RT, Arogundade FA, Yusuph H, Gezawa ID

Available online Jul 13, 2018.

[ Original ] Volume 19, Issue 4, 2010, Pages 427-431


Abstract

Background: C-reactive protein is an acute-phase
proteins, produce in the liver, its release is stimulated by
cytokines (interleukin 6 and tumour necrosis factor alpha).
Elevated level of it is a risk factor for coronary heart
disease. Baseline levels of C-reactive protein in
apparently healthy men and women predict long-term risk
of a first myocardial infarction. Diabetics are at increased
risk for coronary heart disease, data from the
Framingham Study showed a two-to three-fold elevation
in the risk of clinically evident atherosclerotic disease in
patients with type II diabetes compared to those without
diabetes. However, but data regarding CRP in Nigerian
diabetic is lacking.
Method: A cross-sectional study conducted among
patients attending out patient clinic of the Obafemi
Awolowo University Teaching Hospitals complex
(OAUTHC) Ile Ife, Osun State south western Nigeria.
Measurement of C-reactive protein was based on the
principle of solid phase enzyme-linked immunosorbent
assay (ELISA).
Results: A total of 125 consecutive subjects were
recruited comprising 75 patients with type II diabetes
mellitus with or without hypertension and 50 apparently
healthy age-and-sex comparable controls. There was a
significant difference between the mean systolic and
diastolic blood pressures of the patients and controls. The
fasting blood glucose and C-reactive protein were
significantly higher in diabetics compared to controls.
There was a positive and significant correlation between
FBG and CRP in both patients and controls.
Conclusion: This study showed that diabetics have
significantly higher serum C-reactive protein compared to
the apparently controls. Also there was a positive and
significant correlation between C-reactive protein and
fasting blood glucose among both patients and controls


Keywords

diastolic blood pressures,

October - December 2010

Volume 19 | Issue 4

Page Nos. 427-431

Online since Jul 13, 2018

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