Available online Jul 19, 2018.
[ Review ] Volume 23, Issue 4, 2014, Pages 335-343
Introduction:Transosseous wires used in the management of fractures are stainless steel alloys which contain
nickel 14.5%, chromium 17.6%, Iron 62.5% and molybdenum 2.8%. Gradual disintegration of the transosseous
wires release nickel into the blood leading to increase nickel concentration in the blood.Nickel has been found to
have some adverse systemic effects on the body.The aim of this paper is to discuss the sources of Nickel in the
body as well as the systemic adverse effects of Nickel as a degradation product of stainless steel surgical implants.
Methods:A study of pertinent literature on nickel as a content of stainless steel alloy used in implant surgery was
done, taking note also of other sources of nickel in the body,the toxicokinetics of nickel and the related adverse
effects of this metal and its compound in humans.
Results:As outcome,the sources of human exposure to nickel,distribution and metabolism of nickel in the body,
host response to stainless steel wires and the adverse effects of nickel in the body are presented.
Conclusion: It may be necessary to discourage the use of wires or implants containing nickel in the
management of fractures. The need for removal of these implants after they have served their purposes is
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Volume 23 | Issue 4
Page Nos. 335-343
Online since Jul 13, 2018