Available online Jul 19, 2018.
[ Review ] Volume 24, Issue 4, 2015, Pages 363-369
Demarkis et al in 1971 described 27 patients who presented during pueperium with cardiomegaly, abnormal
electrocardiographic findings, congestive heart failure and named the syndrome “peripartum cardiomyopathy”.The
aim of this review is to document the current concepts in the management of peripartum cardiomyopathy.
MATERIALS AND METHODS
A search of the literature was done using PubMed,Goggle scholar and books from authors' collections.
The cause of the disease might be environmental and genetic factors. Diagnostic echocardiographic criteria include
left ventricular ejection fraction of less than 45% or a combination of M- mode fractional shortening of less than 30%
2 and end diastolic dimension of greater than 2.7cm/m . Electrocardiogram, magnetic resonance imaging,
endomyocardial biopsy and cardiac catheterization aid in the diagnosis and management of peripartum
cardiomyopathy. Treatment includes both conventional pharcomological heart failure and peripartum
cardiomyopathy targeted therapies.Therapeutic decisions are influenced by drug safety profiles during pregnancy and
lactation.Mechanical support and transplantation might be necessary in severe cases.
Peripartum cardiomyopathy is an uncommon but life threatening cardiac failure of unknown aetiology encountered in
late pregnancy or postpartum period. Management aims at improving heart failure symptoms through conventional
therapies and then at administering targeted therapies.The risk of recurrence in future pregnancies should always be
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Volume 24 | Issue 4
Page Nos. 363-369
Online since Jul 12, 2018